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1 Introduction Sepsis is a life-threatening condition caused by an uncontrolled response to infection (1)

If pralidoxime is administered before adequate atropinization , it may temporarily worsen life-threatening muscarinic effects, including: Bronchoconstriction Increased respiratory secretions , which can lead to airway obstruction Therefore, clinical guidelines recommend administering atropine before pralidoxime , and this sequence is reflected in autoinjector design (Aman et al., 2021

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No validated human dose, half-life or safety programme was identified

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