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According to the SmPC, the medication has a half-life of approximately one week, resulting in continuous effects on gastric emptying and gut motility throughout the dosing period, meaning gastrointestinal symptoms may occur at any time, though they are often most pronounced in the days following dose escalation

This activation causes a cascade of effects: blood vessel dilation, changes in heart rate variability, and shifts in electrolyte balance

Both are problematic

Supported by numerous randomized controlled trials for knee osteoarthritis, tennis elbow, Achilles tendinopathy, and more

Photoactivation of mutant isocitrate dehydrogenase 2 reveals rapid cancer-associated metabolic and epigenetic changes