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Long-term safety data for semaglutide comes from diabetes trials lasting approximately 2 years and the SELECT cardiovascular outcomes trial with median follow-up of about 3.3 years

Clinical trials lasted 48-68 weeks, with ongoing weight loss throughout

Tubular secretion and reabsorption have high interindividual variability, and both can be saturated which can result in nonlinear pharmacokinetics (Van Roon and Van De Laar 2010

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Use a new sterile needle for each vial access