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At present, Novo Nordisk has developed injection preparations (Ozempic) and oral preparations (Rybelsus) for semaglutide: Ozempic (semaglutide, injection preparation): is a weekly subcutaneous injection preparation (0.5mg or 1mg), suitable for: (1) as an auxiliary means of diet adjustment and exercise to improve blood sugar control in adult patients with type 2 diabetes (2) It is used for adult patients with type 2 diabetes with cardiovascular disease (CVD) to reduce the risk of major adverse cardiovascular events (MACE, including cardiovascular death, non-fatal heart attack, and non-fatal stroke)

Active GLP-1 (7-36) amide Levels This means that GLP-1 (7-36) amide is present at low physiological concentrations, making accurate measurements extremely difficult, particularly in fasted subjects who already have low levels of active GLP-1 2

It means the evidence base is theoretical, anecdotal, and rooted in pharmacokinetic modeling rather than clinical outcomes data

While everyones chasing semaglutide, the real disruption might be what comes next

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Alcohol increases the risk of pancreatitis by direct pancreatic inflammation and by promoting heavy drinking patterns in some people