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The mechanism of ferroptosis and applications in tumor treatment

Triple-hormone-receptor agonist retatrutide for obesity: a Phase 2 trial

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Jena AB, Samal RR, Bhol NK, Duttaroy AK (2023) Cellular red-ox system in health and disease: the latest update

Crucially, FOXO4-DRI selectively induced apoptosis in senescent TM3 Leydig cells by causing nuclear exclusion of active Ser15-phospho-p53, leading to a significant increase in apoptosis rate and altering pro-apoptotic (BAX, cleaved-Caspase3 increase) and anti-apoptotic (BCL-2 decrease) protein levels