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In a 24-week trial in 62 overweight or obese women, 28 with PCOS and 34 without, a reduced-calorie, low-glycemic index diet significantly improved acne, menstrual regularity, and testosterone and SHBG levels

This impairs ATP synthesis, activates apoptotic pathways, and directly compromises cellular survival in energetically demanding, post-mitotic tissues such as the heart and brain (11-16)

10.1128/AAC.49.8.3546-3549.2005 37

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IGF-1 levels were observed to potentially increase by about 28%, which may indicate improved functionality of the growth hormone and IGF-1 axis