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GLP-1 promotes osteogenic differentiation of human ADSCs via the Wnt/GSK-3/-catenin pathway

Tirzepatide has not been studied specifically for osteoarthritis outcomes in a dedicated trial, though weight loss from any intervention typically improves joint pain

Guedes-Correa JF, Torrao F, De Souza Moreira CA, Amorim RMP

Angiopoietin-like protein 3 and 4 in obesity, type 2 diabetes mellitus, and malnutrition: the effect of weight reduction and realimentation

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