qRT-PCR analysis revealed the marked upregulation of CDKN2A (encoding p16) , CDKN1A (encoding p21) , interleukin-8 ( IL-8) , and matrix metalloproteinase ( MMP)-12 expression (Figure 1D)
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Fisetin improves mitochondrial dysfunction and impairment in palmitate-treated hepatocytes and attenuated non-alcoholic fatty liver disease in mice fed a high-fat diet [81]