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Monitor liver enzymes at 12 and 24 weeks if MASLD is present

Gastrointestinal Issues (Most Common) Nausea Vomiting Diarrhea Constipation Abdominal pain Bloating Excess gas Heartburn Fatigue 2

Of those randomized, 1872 subjects received at least one dose of DUPIXENT 300 mg or placebo subcutaneously every 2 weeks (Q2W)

Functional prediction of differentially expressed genes

Symptoms of B12 deficiency can include fatigue, weakness, pale skin, shortness of breath, dizziness, memory problems, mood changes, and tingling or numbness in the hands and feet

Monitoring blood glucose levels, weight changes, and side effects will inform dose adjustments