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The VIP immune response is mediated by specific receptors, namely vasoactive intestinal peptide receptor type 1 (VPAC-1) and type 2 (VPAC-2) [87]

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Deep learning models, such as convolutional neural networks (CNNs), further improve diagnostic precision by identifying subtle features (129), such as intraretinal microvascular abnormalities (IRMAs), that may be missed by human graders (130, 131)