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Nutrients 10(4):522

10.1016/j.pharmthera.2018.03.004 30 DaiP.WangJ.LinL.ZhangY.WangZ

In contrast, ARG2 is expressed in mitochondria of multiple tissues, with the most abundant expression in the kidney and prostate, and mediates arginine/ornithine balance

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It is produced by modifying the Cterminus of the MTII scaffold replacing the terminal amide with a hydroxyl group yielding a related cyclic peptide with a distinct receptorselectivity profile while retaining the lactambridged, enzymatically stable architecture of its parent compound