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Retatrutide is promising because of its triple-agonist mechanism and strong weight-loss data, but current public evidence is not enough to make a firm superiority claim specifically for muscle preservation compared with semaglutide or tirzepatide

Consistently doing more work leads to superior adaptations in muscle and strength gains

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Fasting blood glucose levels often improve first, followed by reductions in post-prandial (after-meal) glucose excursions as gastric emptying slows