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administered into the rats fasted 16 h, and at 10:00 standard chow was given and food intake was measured

One big reason is oxidative stress

(Stockler-Pinto et al ., 2009) Unlike primary antioxidants that can cope with high volumes of free radicals, the secondary (non-enzymatic) antioxidants, such as vitamins, minerals and polyphenols, which are sourced via the diet, have a more limited capacity to quench free radicals

2012;7(6):e38760