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Bruising and swelling are usually minimal

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Common observations in clinical settings include transient gastrointestinal effects that typically subside with dose titration

In some cases, if adhesions or strictures are severe, surgical intervention may be needed to restore normal flow through the small intestine

Nevertheless, as all of these studies assessed only the average levels of methylated DNA in a population of cells, further technical advances will hopefully allow us to shift our attention from epigenome changes in a population of cells grown in vitro toward single cells in their intact niche