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Verdict: Go (Cautious) High demand, but requires strict third-party testing to build trust

10.1159/000450982 32 WangT.SongJ.HuJ.FengS.ZhangH.WangH.et al (2021a)

Chen H, Zhang H, Li AM, Liu YT, Liu Y, Zhang W, Yang C, Song N, Zhan M, Yang S

At 2 years , a large head-to-head cohort presented at ASMBS 2025 showed ~ 24% weight loss after sleeve/bypass vs ~57% with semaglutide/tirzepatide

however, cellular mechanisms related to the central nervous system, particularly glial cell dysfunction associated with astrocytes and microglia [25, 26] are among the most commonly proposed underlying explanations [4, 27, 28]

What Are Satellite Cells and Why Do They Matter