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J Endocrinol (2014) 221(1):T3141
Aging is associated with decreased reduced glutathione in cells and increased oxidized glutathione, indicating a pro-oxidizing shift in redox balance
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Studies have shown that when amyloid-beta and tau are increased, the cells ability to neutralize oxidative stress and mitochondria specific ROS is decreased leading to further tau hyperphosphorylation and neurodegeneration (Alavi Naini and Soussi-Yanicostas 2015)
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