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Tretinoin often causes dryness, peeling, and redness due to increased skin-cell turnover, says double-board-certified facial plastic surgeon Babak Azizzadeh

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Methods Enzymol 173 , 335 (1989)

doi: 10.1016/j.expneurol.2005.01.021

+50% for vitamin C), and has demonstrated a reduction in wrinkle volume of -55.8% in 12 weeks in a clinical trial on 71 women (Pickart et al., BioMed Res Int 2015)

Jackson MJPS, Bolaos J, Bruckdorfer R, Carlssen H, Elliot RM, Flier J, Griffiths HR, Heales S, Holst B, Lorusso M, Lund E, Moskaug JO, Moser U, Di Paola M, Polidori MC, Signorile A, Stahl W, Via-Ribes J, Astley SB: Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function