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10.1172/JCI163669 134 PietrangeloT.FulleS.CosciaF.GigliottiP

Most of our patients are adults (typically ages 2565) who want a proactive approach to aging

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Oral medications may feel easier to obtain, easier to hide, and easier to misuse

Compound selection should be driven by demonstrated brain exposure rather than commercial prominence

SIRT3 (widely expressed in mitochondria-rich tissues such as kidney, heart, brain, and liver tissue), is linked to age-related diseases, cancer, and heart and metabolic diseases, suggesting that it may be a potential therapeutic target [144]