Nomild to moderate nausea does not require stopping treatment, as it typically reflects adaptation rather than harm
However, for those patients who just took the placebo, only 2.4 percent of body fat was lost during those 68 weeks
As well as the above, the clinical trial improved the ability of NK cells to kill their target two-fold, demonstrating a reduction in oxidative stress as well
It may thus be suggested that direct exposure of the gut to the microbiome - capable of synthesizing thiamine antagonists or possessing thiamine-degrading thiaminase II - may first of all affect the gut, leading to gastrointestinal beriberi, especially under conditions of SIBO or other disturbances of the gut microbiome
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These included: Nausea (the most frequently reported adverse effect) Vomiting Diarrhoea Constipation Decreased appetite These effects were generally dose-dependent, occurring more frequently and with greater severity at higher doses