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Ipamorelin functions by binding to ghrelin receptors (GHS-R1a receptors) in the pituitary gland and hypothalamus

Supplementing with L-Arginine can help increase blood circulation to the uterus and ovaries, thus creating an optimal environment for egg production and implantation of a fertilized egg

It is better described as more active at MC1R, rather than fully selective, since most melanocortin peptides can act on multiple receptors

Bruijn N, van Lohuizen R, Boron M, Fitzek M, Gabriele F, Giuliani G et al (2024) Influence of metabolic state and body composition on the action of pharmacological treatment of migraine

They're frequently studied together because their receptor pathways complement each other well, making them a natural pairing for researchers looking at how these two systems interact

Currently, IQVIA estimates 5.1M patients are taking GLP-1 drugs, including 4.3M for T2D and 800K patients for weight loss