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In mice heterozygous for the SPT subunit SPTLC2 (serine palmitoyltransferase, long-chain base subunit 2) there is a reduction in peripheral ceramide levels and improved insulin sensitivity when these animals are fed a high-fat diet

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Non-medication strategies For some patients, lifestyle interventions or specialized nutrition and fitness programs can help sustain progress without medication

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Notably, this therapeutic combination also induced long-lasting immune memory [184]