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For those using other licensed weight loss medicines such as semaglutide 2.4 mg (Wegovy) or tirzepatide (Mounjaro) and experiencing hair loss, it is advisable to speak to a GP or pharmacist if: Hair shedding is noticeably increased when washing or brushing Shedding persists for more than three to six months There is visible thinning or patchy hair loss Hair loss is accompanied by other symptoms such as fatigue, cold intolerance, or brittle nails , which may suggest an underlying thyroid or nutritional deficiency The following are red flag features that warrant prompt medical review and possible referral to a dermatologist: Painful, inflamed, or scarring scalp changes Rapidly progressive or patchy hair loss, including loss of eyebrows or eyelashes Suspected tinea capitis (scalp ringworm), particularly in children Systemic symptoms suggesting an underlying condition A GP can arrange relevant investigations, which should be guided by clinical history and examination

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At the same time, Lactobacillus rhamnosus derived extracellular Vesicles can regulate the process of adipocyte metabolism, inhibit the excessive release of inflammatory factors, reduce the chronic inflammatory reaction of adipose tissue, and improve dyslipidemia (Tong et al., 2021)

Engineering peptide stability to generate sustained in vivo GLP-1R activation in vivo Cleavage after position W25 was also detected during production for some of our initial GLP-1 analogue peptide-antibody fusions and we hypothesized that W25 would be particularly labile

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