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In cellular models, 2012 was able to potently and effectively reduce the number of FAK-containing focal adhesions with a sub-micromolar IC 50 value of 0.80 M, which was on par with the K D of 0.8 M at the helix 23 FAT domain site

GLP-1RAs also reduce macrophage activation and TNF- expression in vivo through the PKA activation and NF-B inhibition in an LPS-induced allergic mouse model [121]

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