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This study was approved by the Washington University Institution Review Board

Curcumin, a Potential Inhibitor of MMP-2 in Human Laryngeal Squamous Carcinoma Cells HEp2

The Data Safety and Monitoring Board reviewed blinded data and had two meetings

Maddah M, Karami L (2021) An atomistic investigation on the interaction of distamycin A and its derivative with the telomeric G-Quadruplex as anticancer agents by molecular dynamics simulation

Intriguingly, a recent randomised controlled trial found that metformin significantly improved depressive symptoms in patients with treatment-resistant bipolar depression [134]

Patients considering these therapies should understand the possible side effects, their own risk factors, and the warning signs that demand urgent attention