Or does the drug directly impact cancer cells
This was examined by assessing associations between frequency of polymorphisms in key metabolism enzyme genes and latitude, with findings unsupportive of this hypothesis but suggesting that folate genotypes are selected to maintain homeostasis within the folate system
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Huang Y, Wang H, Tang G, Zhou Z, Zhang X, Liu Y, Yan G, Wang J, Hu G, Xiao J, Yan W, Cao Y
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5,299 This microvascular impairment reduces oxygen and nutrient delivery to peripheral nerves, leading to nerve ischemia and hypoxia