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Obesity is associated with low-grade systemic inflammation, characterized by increased levels of inflammatory markers such as Toll-like receptor 4 (TLR4), tumor necrosis factor-alpha (TNF-), IL-6, IL-1 [36], IL 17, leptin [37], and resistin [38]

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Alhaider AA, Korashy HM, Sayed-Ahmed MM, Mobark M, Kfoury H, Mansour MA

The market they are both chasing is huge, and largely untapped

Three pathways still qualify a patient: a documented allergy to an inactive ingredient in the approved product, a dose or route not commercially available such as a microdose below 2.5 mg, or a clinically meaningful combination such as tirzepatide with niacinamide or B12