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doi: 10.3389/fncel.2021.673217 356 CostaDCTannockCBrostoffJ

demonstrated that HDAC inhibition by sulforaphane induces acetylated histones on the promoters of genes such as P21 and bax , and the derepressed genes trigger cell cycle arrest and apoptosis in transformed cells and microadenomas, thereby suppressing polyp formation in the GI tract 46

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