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According to the researchers, there are several mechanisms that may explain why GLP-1 receptor agonists were associated with these reductions among people with HS

This greatly improves their life quality

Over the following weeks most people notice steadier energy and fewer afternoon crashes first (weeks 12), then early fat loss around the midsection with workouts feeling more productive (weeks 24), then measurable body-fat reduction and better endurance and recovery (weeks 48), with metabolic markers like glucose and triglycerides often improving by week 8+

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Either way, knowing what to expect makes your decision easy and keeps your routine on track