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4.2.3 Clinical manifestations and diagnostic criteria 4.2.3.1 Age-dependent clinical manifestations In most patients with atopic eczema, the disease begins in infancy between 3 and 12 months of age (Hill & Sulzberger, 1935) as an erythematous, squamous or papulo-vesiculous inflammation, which may worsen to the point of exudation

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These features may mean that covalent inhibitors are required for inhibition of cellular GPX4, which often have poor selectivity and pharmacokinetic properties