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Other advances have contributed to the FDA approval of three new medications in 2017 and 2019 for management of sickle cell disease, with several other drugs currently under development

First-line management focuses on patient education, reassurance, and identifying individual triggers through dietary and lifestyle assessment

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[33] [34] Kidneys Painless passage of blood or protein in the urine may often be the only presenting sign of kidney involvement

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Trubalski M, Markiewicz-Gospodarek A, erebiec M, Poleszak J, Szczotka M, et al