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Vdac regulation: a mitochondrial target to stop cell proliferation

The O 2 concentration continued to increase steadily and remained stable with increasing time

The length of telomeres shortens progressively with each cell division (mitosis) and is strongly associated with lifespan (Heidinger et al., 2012

This overlap is the main reason for staggered titration - start one compound first, build tolerance, then add the second

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Afterwards, alternative splicing, mRNA stability, translation, and protein degradation control the abundance of enzymes (long-term regulation) 69