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2000 Jun;10(2):199-207

Endres LK, Straub H, McKinney C, Plunkett B, Minkovitz CS, Schetter CD, et al

Interestingly, after discontinuing Pycnogenol and placebo intake in the fifth cycle of the study, subjects of the Pycnogenol group reported a continuation of the trend, as their need for analgesics was even more reduced (50% compared to baseline), while women of the placebo group experienced a rapid return to analgesics