Statements Author contributions AC and GLG contributed to conception of the review
The goal is to confirm that weight loss is improving health, not only changing the scale
Beyond being a waste of money, the interaction between dying probiotic organisms and antibiotic-disrupted gut flora can worsen digestive symptoms
Furthermore, the reduced glucagon levels can lead to a decrease in food intake and an increase in energy expenditure, resulting in a favorable shift toward weight loss
In a separate study , published in JAMA in August 2025, the same researchers found that, across ages, GLP-1s were associated with lower risk of some obesity-related cancers, such as endometrial, ovarian, and meningioma cancers, but with an increased risk of kidney cancer, and nonsignificant changes for several other cancers
Common side effects reported in the study included nausea, diarrhea, constipation, and abdominal discomfort