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The trial was conducted according to the Declaration of Helsinki (World Medical Association

Studies have found that patients on GLP-1 drugs experience acid reflux at rates significantly higher than the general population

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However, severe abdominal pain, bloody stools, persistent vomiting, or constipation lasting more than 23 weeks despite treatment warrants immediate medical evaluation

The biologically active circulating form of GLP-1 is GLP-1 (7-36) amide, a 30-amino-acid peptide generated from post-translational processing of the proglucagon precursor and featuring a naturally occurring C-terminal amidation (-NH) [2]