Nat Neurosci 6 : 11621168
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In general pharmacology, titration means making cautious, incremental changes while monitoring tolerance , because faster changes can increase the likelihood of adverse effects
STEP-4 gave every participant a 20-week course of semaglutide 2.4 mg once weekly, and produced a mean weight loss of 10.6%, before randomisation to either continued semaglutide treatment or exchange to placebo for an additional 48 weeks
This discovery has sparked considerable scientific interest in whether GLP-1 receptor agonists might offer neuroprotective benefits beyond their established metabolic effects, particularly in conditions such as Parkinson's disease
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