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Denominator (All Adults) The number of adult patients who have either a recorded body mass index (BMI) or a prescription, medication dispense, or patient recorded medication in the quarter

Iles KE, Liu RM

But you've reduced effective dose by nearly half through timing alone

doi: 10.3389/fimmu.2025.1602235 Received 29 March 2025 Accepted 19 May 2025 Published 04 June 2025 Volume 16 - 2025 Edited by Yali Zheng, Xiamen University, China Reviewed by Hong Yu, Nanyang Technological University, Singapore Jiaxin Ma, Xiamen University, China Updates Copyright 2025 Habiballah, Li and Jiang

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249,250 Acute systemic injections of the bacterial antigen lipopolysaccharide (LPS) in mice induces diffuse inflammatory changes in the CNS and mimics this sickness behaviour and is often used as a model to study effects of inflammation on CNS functions