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3.6 The inhibitory effect on BMSCs osteogenic differentiation following the knockdown of LRP5 was alleviated by semaglutide By the manufacturers protocols, LRP5 mRNA levels were diminished by 70% as determined 48 h following siRNA intervention (Figure 5E)

Conversely, endotoxin-dependent hyperinsulinemia was markedly blunted by the use of GLP-1 receptor antagonists or in IL-6 knockout mice (61)

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