However, in resistant patients, oxidative stress causes a conformational change in Keap1, leading to the release of NRF2, which translocates to the nucleus and binds to antioxidant response element (ARE), activating the expression of downstream antioxidant genes, including GPX4, NQO1, HO-1 and SOD1 [33], and promoting the synthesis of GSH, as illustrated in Fig
Therapeutic targeting of ras/raf/mapk pathway by natural products: A systematic and mechanistic approach for neurodegeneration
References 1.Arjinpathana N., Asawanonda P
Ice packs for 1520 minutes, several times a day, can reduce inflammation and swelling
In fact, a cell is now considered to be healthy if it has a GSH/GSSG ratio of more than 100, ie a much higher amount of GSH than GSSG
Transplant., 7, 1071-1079 11