PFD prevented liver injury and fibrosis associated with decreased apoptosis of liver cells in WD-fed MC4R-KO mice [88]
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As a result of decrease GSH concentration which affect the intracellular redox state will which shift more oxidants cause hepatocellular injury and release of liver enzymes (Figure 2), which could require fast reduction of oxidized cysteines allowing replenish the substrate for GSH
FDA, updated Van Wagoner, R