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Selective or highly selective vagotomy may permit -synuclein pathology from elsewhere in the GI tract to still reach the vagus nerve and, thereafter, the brainstem

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Nevertheless, greater use of uricase knock-out animals and similar humanising paradigms may prove valuable in studying the interaction of UA with clinically relevant models of PD neurodegeneration

Expression of a catalytically inactive mutant form of glutathione peroxidase 4 (Gpx4) confers a dominant-negative effect in male fertility