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Moving from 0.5% to 1%, or from 1% to 2%, represents appropriate steps

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a mean increase of 6.9% among participants switched to placebo (difference of 14.8 percentage points

MT-II binds primarily to the MC1 and MC4 receptors, and to a lesser extent to MC3

10.1038/s41598-018-25603-5 Sci

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