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Choose the same day each week for consistency (many prefer Sunday evenings) Allow refrigerated medication to reach room temperature before injecting Clean the injection site with alcohol and let it dry completely Pinch a fold of skin and insert the needle at a 45-90 degree angle Inject slowly over 5-10 seconds Hold the needle in place for 10 seconds after completing the injection Rotate sites in a systematic pattern (left abdomen, right abdomen, left thigh, right thigh) Injection timing preferences vary among users

Patients should also be aware of potential hair loss , which affects some GLP-1 users due to rapid weight loss and caloric restriction rather than the medication itself

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Some stimulate growth hormone to trigger lipolysis directly