Recent advances in FcR biology have identified four activating FcRs (FcRI, FcRIIa, FcRIIc and FcRIIIa) and one inhibitory FcR (FcRIIb) that have various Fc ligand specificities and cell-signalling motifs 10
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Yes, most strength protocols benefit from cycling - typically 8-12 weeks on followed by 4-6 weeks off
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This may reflect receptor downregulation from continuous use
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