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The protective effect of HO-1 in diabetic retinopathy is not only reflected in the inhibition of inflammation and oxidative stress but also promoted microglia polarization from the M1 state (pro-inflammatory) towards the M2 state (anti-inflammatory) [159]

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The anti-aging peptides category also intersects with lupus management, as the accelerated cellular aging driven by chronic inflammation may be partially addressed through peptides that support telomere maintenance, mitochondrial function, and cellular repair processes