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Both can cause nausea, diarrhea, constipation, and vomiting (1)

But the two drugs differ in their mechanisms, making tirzepatide potentially more effective for some individuals

These agents enhance glucose-dependent insulin secretion from pancreatic beta cells, suppress inappropriate glucagon release, slow gastric emptying, and promote satiety through central nervous system pathways

Epilepsy in GDH-HI patients is typically insensitive to anti-epileptic drugs

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However, dedicated analyses examining whether women experience different rates of adverse events, different magnitudes of weight loss, or distinct metabolic responses compared to men have not yet been published in peer-reviewed literature