Niacinamide Fully Compatible Despite old internet rumors that niacinamide and copper peptides cancel each other out, modern research and formulation practice show they pair well at cosmetic concentrations
Id say talk to your doctor, consider GHK-Cu as a potentially useful tool as part of a supervised treatment plan with antioxidant or hormone support, and monitor updated clinical trial results before long-term use
Recent human topical evidence A 2023 IRB-approved 21-woman topical trial of NEEL gel (a stabilized GHK-Cu topical) reported an average 28% increase in skin collagen density at 3 months, with a top quartile reporting 51%
Mild side effects like nausea or injection site discomfort may occur
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Its also rich in antioxidants, Vitamin A, Vitamin C, and fiber, making it a complete skin food