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Within months of insulins clinical introduction, investigators began experimenting with oral dosing, often administering vast quantities of crude pancreatic extracts to replicate the glucose-lowering effects observed with injection ( During the pioneering era from the 1920s through the 1950s, oral peptide delivery was pursued primarily through empirical experimentation

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Consult with your healthcare provider or registered dietitian for personalized advice tailored to your specific condition

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For example, only eight studies assessed treatment with the newer GLP-1 drugs, and the maximum follow-up period in these studies was 12 months after medication stopped