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Mechanisms include: Increased oxidative stress Glutathione depletion Mitochondrial toxicity Induction of liver detox enzymes Importantly, GGT can rise even with moderate, socially acceptable alcohol intake , especially in genetically susceptible individuals

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Doses above 10 grams increase gastrointestinal side effects without proportional benefit for most individuals

NADH is required for mitochondrial oxidative phosphorylation and ATP production

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