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Nadolsky says clinicians aim for patients to lose somewhere around a half of a percent to one percent of their total body weight per week. If weight loss is slower than that, we go up," he says

By comparison, the DPP-4 inhibitors, saxagliptin and alogliptin, carry a regulatory warning about the finding of an increased risk of hospitalization for heart failure in treated patients enrolled in large-scale trials carried out with these drugs [57]

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