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A progressive decline in insulin secretion from beta-cells is a hallmark of T2D progression [27]

PIP 3 also interacts with proteins possessing a pleckstrin homology (PH) domain, such as protein kinases, including Akt and Bruton's tyrosine kinase (BTK)

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Table 3 shows the comparison of L-carnitine (C0), total carnitines and 13 long-chain acylcarnitines, as well as total acylcarnitines, between the congenital hypothyroid patients with fatigue or fatigue-related symptoms and healthy controls